Palladium-Catalyzed Dehydrogenative C-2 Alkenylation of 5-Arylimidazoles and Related Azoles with Styrenes

Palladium-catalyzed direct C-3 oxidative alkenylation of phosphachromones.

A method for the synthesis of C-3 alkenylated phosphachromones was developed using a direct intermolecular C-3 alkenylation with activated and non-activated alkenes through C-H activation under aerobic conditions.

Palladium(II)-catalyzed direct alkenylation of dihydropyranones.

A palladium(II)-catalyzed direct alkenylation reaction of dihydropyranones was developed. Various substituted dihydropyranones could afford the desired products in reasonable yields. And different acrylates were found to be good coupling partners in this coupling reaction. A Pd(0)/Pd(II) catalytic pathway was proposed to be involved in this coupling reaction.

Palladium-Catalyzed Alkenylation by the Negishi Coupling

Palladium-catalyzed ortho-C-H alkenylation of 2-benzyl-1,2,3-triazoles.

A mild and efficient method for the direct alkenylation of 2-benzyl-1,2,3-triazoles via Pd-catalyzed C-H bond activation was developed. This protocol was compatible with various substrates and gave the corresponding products in good to excellent yields. Thus, the present study provides a novel and valuable method for the synthesis of 2-benzyl-1,2,3-triazole derivatives.

Palladium-catalyzed desulfitative arylation of azoles with arylsulfonyl hydrazides.

Palladium-catalyzed desulfitative and denitrogenative arylation of azoles with arylsulfonyl hydrazides has been achieved. A broad scope of azoles and arylsulfonyl hydrazides has been used to produce arylated azoles in high yields.